Literature summary for 4.2.2.20 extracted from

Jefferson, S.C.; Tester, N.J.; Howland, D.R.
Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection (2011), J. Neurosci., 31, 5710-5720.

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Application

Application	Comment	Organism
medicine	intraspinal delivery of chondroitinase ABC, following T10 hemisections in adult cats, enhances adaptive movement features during a skilled locomotor task and/or promotes plasticity of spinal and supraspinal circuitry. Chondroitinase ABC enhances crossing of a peg walkway post-spinal cord injury and significantly improves ipsilateral hindlimb trajectories and integration into a functional forelimb-hindlimb coordination pattern. Recovery of these complex movements is associated with significant increases in neurofilament immunoreactivity immediately below the spinal cord injury in the ipsilateral white and contralateral gray matter. Significantly more retrogradely labeled right axotomized red nucleus neurons are seen in chondroitinase ABC-treated compared with control-treated cats indicating that a larger number of red nucleus neurons in chondroitinase ABC-treated cats had axons below the lesion level	Proteus vulgaris

Organism

Organism	UniProt	Comment	Textmining
Proteus vulgaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Proteus vulgaris	-

Synonyms

Synonyms	Comment	Organism
Ch'ase	-	Proteus vulgaris

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Release 2023.1 (January 2023)