Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.2.20 extracted from

  • Massey, J.M.; Amps, J.; Viapiano, M.S.; Matthews, R.T.; Wagoner, M.R.; Whitaker, C.M.; Alilain, W.; Yonkof, A.L.; Khalyfa, A.; Cooper, N.G.; Silver, J.; Onifer, S.M.
    Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3 (2008), Exp. Neurol., 209, 426-445.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine it is shown that cervical spinal cord injury (SCI) results in the significantly increased expression of the chondroitin sulfate proteoglycans (CSPGs) NG2, neurocan, and brevican in the distant denervated dorsal column nuclei (DCN). The CSPGs present a potent barrier to reinnervation by regenerating axons from microtransplanted adult sensory neurons following SCI that can be overcome by chondroitinase ABC (chABC) application and increased neurotrophin-3 (NT-3) expression within the nucleus Proteus vulgaris

Organism

Organism UniProt Comment Textmining
Proteus vulgaris
-
-
-

Synonyms

Synonyms Comment Organism
chABC
-
Proteus vulgaris
chondroitinase ABC
-
Proteus vulgaris