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Literature summary for 4.2.2.19 extracted from

  • Denholm, E.M.; Lin, Y.Q.; Silver, P.J.
    Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasion (2001), Eur. J. Pharmacol., 416, 213-221.
    View publication on PubMed
Search for more literature for 4.2.2.19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dermatan sulfate Homo sapiens substrate is involved in activities related to metastasis ?
-
 ?
additional information Homo sapiens enzyme inhibits endothelial and melanoma proliferation and invasion, but to a lesser extent than chondroitin AC lyase, EC 4.2.2.5, enzyme has no effect on gelatinase excretion by melanoma cells, enzyme does not activate caspase-3 activity and apoptosis in melanoma and endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Homo sapiens
-
SK-MEL cell melanoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dermatan sulfate
-
 Homo sapiens ?
-
 ?
dermatan sulfate substrate is involved in activities related to metastasis Homo sapiens ?
-
 ?
additional information enzyme inhibits endothelial and melanoma proliferation and invasion, but to a lesser extent than chondroitin AC lyase, EC 4.2.2.5, enzyme has no effect on gelatinase excretion by melanoma cells, enzyme does not activate caspase-3 activity and apoptosis in melanoma and endothelial cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chondroitinase B
-
 Homo sapiens