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Literature summary for 4.2.2.1 extracted from

  • Reese, K.L.; Aravindan, R.G.; Griffiths, G.S.; Shao, M.; Wang, Y.; Galileo, D.S.; Atmuri, V.; Triggs-Raine, B.L.; Martin-Deleon, P.A.
    Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm (2010), Mol. Reprod. Dev., 77, 759-772.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.2.1

Protein Variants

Protein Variants Comment Organism
additional information construction of Hyal3 null mutants Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
acrosome
-
 Mus musculus
-
-
additional information differential localization of sperm isozymes, pH-dependent, overview Mus musculus
-
-
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Homo sapiens 5886
-
soluble
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 x * 44000 + x * 47000, HYAL3 in sperm, SDS-PAGE Mus musculus
47000
-
 x * 44000 + x * 47000, HYAL3 in sperm, SDS-PAGE Mus musculus
47000
-
 x * 47000 + x * 55000, HYAL3 in sperm, SDS-PAGE Homo sapiens
55000
-
 x * 47000 + x * 55000, HYAL3 in sperm, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 several different isozymes
-
Mus musculus
-
 several different isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Homo sapiens
-
epididymis Hyal3 and SPAM1 Mus musculus
-
additional information Hyal3 tissue expreesion pattern, overview Homo sapiens
-
additional information Hyal3 tissue expreesionpattern, overview Mus musculus
-
sperm acidic, somatic hyaluronidase 3 exists in two isoforms, and resides on the plasma membrane over the head and midpiece Homo sapiens
-
sperm caput, corpus, and caudal mouse sperm. Acidic, somatic hyaluronidase 3 exists in two isoforms, and resides on the plasma membrane over the head and midpiece Mus musculus
-
testis
-
 Homo sapiens
-
testis HYAL3, which belongs to the somatic subgroup of hyases, is abundantly expressed in the testis Mus musculus
-

Subunits

Subunits Comment Organism
? x * 44000 + x * 47000, HYAL3 in sperm, SDS-PAGE Mus musculus
? x * 47000 + x * 55000, HYAL3 in sperm, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
acidic hyase
-
 Mus musculus
acidic hyase
-
 Homo sapiens
HYAL3
-
 Mus musculus
HYAL3
-
 Homo sapiens
hyaluronidase 3
-
 Mus musculus
hyaluronidase 3
-
 Homo sapiens
HYase
-
 Mus musculus
HYase
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
3 7 high activity at pH 3.0-4.0, lower activity at pH 7.0 Mus musculus

General Information

General Information Comment Organism
malfunction Hyal3 null sperm shows delayed cumulus penetration and reduced acrosomal exocytosis, but full fertility Mus musculus
physiological function in general, neutral-active or reproductive hyaluronidases, i.e. hyases, exemplified by sperm adhesion molecule 1, SPAM1, are responsible for hyaluronan digestion in the egg vestments and for sperm-zona binding, but murine SPAM1 has acidic activity. Presence of HYAL3 in mouse sperm where it contributes to hyase activity at pH 3, 4 and 7 as well as to cumulus penetration and the induction of the acrosome reaction Mus musculus
physiological function in general, neutral-active or reproductive hyaluronidases, i.e. hyases, exemplified by sperm adhesion molecule 1, SPAM1, are responsible for hyaluronan digestion in the egg vestments and for sperm-zona binding. Presence of HYAL3 in human sperm where it contributes to hyase activity at pH 3, 4 and 7 as well as to cumulus penetration and the induction of the acrosome reaction Homo sapiens