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Literature summary for 4.2.2.1 extracted from

  • Salmen, S.; Hoechstetter, J.; Kaesbauer, C.; Paper, D.H.; Bernhardt, G.; Buschauer, A.
    Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae (2005), Planta Med., 71, 727-732.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
beta1,4-galacto-oligosaccharides partially sulfated and non-sulfated forms, IC50 values Streptococcus agalactiae
additional information inhibition curves, overview Streptococcus agalactiae
partially sulfated neomycin the non-sulfated neomycin is not inhibitory Streptococcus agalactiae
partially sulfated planteose the non-sulfated planteose is not inhibitory, IC50 is 0.015 mM Streptococcus agalactiae
partially sulfated verbascose 2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.030 mM and 0.001 mM Streptococcus agalactiae
sulfated 2-hydroxyphenyl monolactobioside IC50 is 0.35 mM Streptococcus agalactiae
sulfated hydroquinone galactoside IC50 is 0.080 mM Streptococcus agalactiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronic acid Streptococcus agalactiae
-
?
-
?
hyaluronic acid Streptococcus agalactiae 4755
-
?
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus agalactiae
-
gene hylB4755
-
Streptococcus agalactiae 4755
-
gene hylB4755
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation purified enzyme Streptococcus agalactiae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronic acid
-
Streptococcus agalactiae ?
-
?
hyaluronic acid from rooster comb Streptococcus agalactiae ?
-
?
hyaluronic acid
-
Streptococcus agalactiae 4755 ?
-
?
hyaluronic acid from rooster comb Streptococcus agalactiae 4755 ?
-
?

Synonyms

Synonyms Comment Organism
hylB4755
-
Streptococcus agalactiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Streptococcus agalactiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Streptococcus agalactiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
the non-sulfated planteose is not inhibitory, IC50 is 0.015 mM Streptococcus agalactiae partially sulfated planteose
0.03
-
2 forms, the non-sulfated verbascose is not inhibitory, IC50 are 0.030 mM and 0.001 mM Streptococcus agalactiae partially sulfated verbascose
0.08
-
IC50 is 0.080 mM Streptococcus agalactiae sulfated hydroquinone galactoside
0.35
-
IC50 is 0.35 mM Streptococcus agalactiae sulfated 2-hydroxyphenyl monolactobioside