Cloned (Comment) | Organism |
---|---|
complementation of an enzyme-deficient mutant strain by expression of hysA | Staphylococcus aureus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inactivation of gene hysA by insertion of ermC, encoding the erythromycin determinant, from plasmid pE194 resulting in mutant strains HL-6, HL-13T, and HL-16T, determination of virulence and pathogenicity of wild-type strain 8325-4, and mutant strains HL-6, HL-13T, and HL-16T, WA250, deficient in regulator agr, and PC1839, deficient in regulator sar, in mice, overview | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronic acid | Staphylococcus aureus | degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor | hyaluronic acid oligomers | - |
? | |
hyaluronic acid | Staphylococcus aureus NCTC 8325 | degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor | hyaluronic acid oligomers | - |
? | |
additional information | Staphylococcus aureus | global regulators sar and agr are involved in enzyme regulation | ? | - |
? | |
additional information | Staphylococcus aureus NCTC 8325 | global regulators sar and agr are involved in enzyme regulation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
strain 8325-4, gene hysA | - |
Staphylococcus aureus NCTC 8325 | - |
strain 8325-4, gene hysA | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | wild-type enzyme expression is maximal during mid-exponential growth phase | Staphylococcus aureus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hyaluronic acid | degradation | Staphylococcus aureus | hyaluronic acid oligomers | - |
? | |
hyaluronic acid | degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor | Staphylococcus aureus | hyaluronic acid oligomers | - |
? | |
hyaluronic acid | degradation | Staphylococcus aureus NCTC 8325 | hyaluronic acid oligomers | - |
? | |
hyaluronic acid | degradation of hyaluronate in connective tissue of hosts to facilitate invasion by subcutaneous infection, the enzyme is an essential bacterial virulence factor | Staphylococcus aureus NCTC 8325 | hyaluronic acid oligomers | - |
? | |
additional information | global regulators sar and agr are involved in enzyme regulation | Staphylococcus aureus | ? | - |
? | |
additional information | global regulators sar and agr are involved in enzyme regulation | Staphylococcus aureus NCTC 8325 | ? | - |
? |