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Literature summary for 4.2.1.99 extracted from

  • Tabuchi, T.; Umetsu, H.; Aoki, H.; Uchiyama, H.
    Characteristics of 2-methylisocitrate dehydratase, isolated from Yallowia lipolytica, in comparison with aconitase (1995), Biosci. Biotechnol. Biochem., 59, 2013-2017.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2R,3S-Isocitrate competitive Yarrowia lipolytica
iodoacetate weak Yarrowia lipolytica
PCMB weak Yarrowia lipolytica
threo-DL-Isocitrate weak Yarrowia lipolytica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate Yarrowia lipolytica the enzyme is involved in methylcitric acid cycle for propionate metabolism ?
-
?
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate Yarrowia lipolytica constitutively synthesized, no regulatory function in the methylcitric acid cycle. The enzyme is supposed to have evolutionarily developed from a hypothetical and prototypical isocitrate dehydratase ?
-
?

Organism

Organism UniProt Comment Textmining
Yarrowia lipolytica
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate
-
Yarrowia lipolytica (Z)-But-2-ene-1,2,3-tricarboxylate + H2O
-
?
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate the enzyme is involved in methylcitric acid cycle for propionate metabolism Yarrowia lipolytica ?
-
?
(2S,3R)-3-Hydroxybutane-1,2,3-tricarboxylate constitutively synthesized, no regulatory function in the methylcitric acid cycle. The enzyme is supposed to have evolutionarily developed from a hypothetical and prototypical isocitrate dehydratase Yarrowia lipolytica ?
-
?

Cofactor

Cofactor Comment Organism Structure
additional information no cofactor required Yarrowia lipolytica