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Literature summary for 4.2.1.92 extracted from
- Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase (2012), J. Biol. Chem., 287, 24139-24147.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | heme ligand of the cytochrome P450 enzyme | Plexaura homomalla |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (8R)-hydroperoxyeicosatetraenoic acid | Plexaura homomalla | the substrate is converted to an unstable allene oxide product via the FeIV-OH intermediate, Compound II, the native enzyme shows a strong preference for its natural substrate | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plexaura homomalla | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (8R)-hydroperoxyeicosatetraenoic acid | the substrate is converted to an unstable allene oxide product via the FeIV-OH intermediate, Compound II, the native enzyme shows a strong preference for its natural substrate | Plexaura homomalla | ? | - |
? | |
| (8R)-hydroperoxyeicosatetraenoic acid | the substrate is converted to an unstable allene oxide product via the FeIV-OH intermediate, Compound II | Plexaura homomalla | ? | - |
? | |
| (8R)-hydroxyeicosatetraenoic acid | the native, unmodified enzyme shows no activity with (8R)-hydroxyeicosatetraenoic acid, but the oxidized enzyme epoxidizes the substrate analogue stereospecifically on the 9,10-double bond to form (8R)-hydroxy-(9R,10R)-trans-epoxy-eicosa-(5Z,11Z,14Z)-trienoic acid as the predominant product, via Compound I (FeV=O) intermediate | Plexaura homomalla | (8R)-hydroxy-(9R,10R)-trans-epoxy-eicosa-(5Z,11Z,14Z)-trienoic acid | erythro and threo diastereomers of (8R)-hydroxy-9,10-trans-epoxy-eicosa-5Z,11Z,14Z-trienoate | ? | |
| additional information | the native enzyme is completely unreactive with polyunsaturated fatty acids or their hydroxylated analogues. Mass spectrometric product analysis, overview | Plexaura homomalla | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cAOS | - |
Plexaura homomalla |
| catalase-related allene oxide synthase | - |
Plexaura homomalla |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Plexaura homomalla |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Plexaura homomalla |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P450 | - |
Plexaura homomalla |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | allene oxide synthase and its relationship to the catalytic cycle of cytochrome P450s, overview | Plexaura homomalla |
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