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Literature summary for 4.2.1.92 extracted from

  • Jernerén, F.; Garscha, U.; Hoffmann, I.; Hamberg, M.; Oliw, E.H.
    Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus (2010), Biochim. Biophys. Acta, 1801, 503-507.
    View publication on PubMed
Search for more literature for 4.2.1.92

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(8R)-hydroperoxylinoleic acid + H2O Aspergillus clavatus
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 (5S,8R)-dihydroxylinoleic acid
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 ?
(8R)-hydroperoxylinoleic acid + H2O Aspergillus clavatus
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 (8R,11S)-dihydroxylinoleic acid
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 ?
additional information Aspergillus clavatus two hydroperoxide isomerases in Aspergillus clavatus acting on hydroperoxylinoleic acid: the 5,8-linoleate diol synthase exhibiting 5,8-hydroperoxide isomerase activity, and the 8, 11-linoleate diol synthase exhibiting 8,11-hydroperoxide isomerase activity, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Aspergillus clavatus
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(8R)-hydroperoxylinoleic acid + H2O
-
 Aspergillus clavatus (5S,8R)-dihydroxylinoleic acid
-
 ?
(8R)-hydroperoxylinoleic acid + H2O
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 Aspergillus clavatus (8R,11S)-dihydroxylinoleic acid
-
 ?
additional information two hydroperoxide isomerases in Aspergillus clavatus acting on hydroperoxylinoleic acid: the 5,8-linoleate diol synthase exhibiting 5,8-hydroperoxide isomerase activity, and the 8, 11-linoleate diol synthase exhibiting 8,11-hydroperoxide isomerase activity, overview Aspergillus clavatus ?
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 ?

Synonyms

Synonyms Comment Organism
5,8-hydroperoxide isomerase
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 Aspergillus clavatus
8,11-hydroperoxide isomerase
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 Aspergillus clavatus
hydroperoxide isomerase
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 Aspergillus clavatus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Aspergillus clavatus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Aspergillus clavatus

General Information

General Information Comment Organism
evolution phylogenetic analysis and sequence comparisons of 5,8-linoleate diol synthase, overview Aspergillus clavatus
metabolism the enzymes are involved in the biosynthesis of (8R,11S)-dihydroxylinoleic acid via isomerization of (8R)-hydroperoxylinoleic acid to (5S,8R)-dihydroxylinoleic acid and to (8R,11S)-dihydroxylinoleic acid by abstraction of the pro-S hydrogens at C-5 and C-11 of (8R)-hydroperoxylinoleic acid, respectively, followed by suprafacial oxygenation Aspergillus clavatus