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Literature summary for 4.2.1.92 extracted from

  • Cho, K.B.; Lai, W.; Hamberg, M.; Raman, C.S.; Shaik, S.
    The reaction mechanism of allene oxide synthase: interplay of theoretical QM/MM calculations and experimental investigations (2011), Arch. Biochem. Biophys., 507, 14-25.
    View publication on PubMed
Search for more literature for 4.2.1.92

Protein Variants

Protein Variants Comment Organism
F137L site-directed mutagenesis Arabidopsis thaliana
F137L/S155A site-directed mutagenesis Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
13-hydroperoxy-9,11-octadecadienoic acid Arabidopsis thaliana wild-type AOS activity (10E,12Z)-12-[(3S)-3-methyl-3-propyloxiran-2-ylidene]dodec-10-enoic acid + H2O
-
 ?
13-hydroperoxy-9,11-octadecadienoic acid Arabidopsis thaliana activity of AOS mutant F137L (10E,12Z)-13-[(2-hydroxypentan-2-yl)oxy]trideca-10,12-dienoic acid + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Reaction

Reaction Comment Organism Reaction ID
(9Z,11E,15Z)-(13S)-hydroperoxyoctadeca-9,11,15-trienoate = (9Z,15Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate + H2O reaction mechanisms of wild-type AOS and mutant F137L, QM/MM calculations, overview Arabidopsis thaliana
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
13-hydroperoxy-9,11-octadecadienoic acid wild-type AOS activity Arabidopsis thaliana (10E,12Z)-12-[(3S)-3-methyl-3-propyloxiran-2-ylidene]dodec-10-enoic acid + H2O
-
 ?
13-hydroperoxy-9,11-octadecadienoic acid activity of AOS mutant F137L Arabidopsis thaliana (10E,12Z)-13-[(2-hydroxypentan-2-yl)oxy]trideca-10,12-dienoic acid + H2O
-
 ?

Synonyms

Synonyms Comment Organism
allene oxide synthase
-
 Arabidopsis thaliana
AOS
-
 Arabidopsis thaliana