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Literature summary for 4.2.1.92 extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Marnett, L.J.; Brash, A.R.
    The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase (2003), Proc. Natl. Acad. Sci. USA, 100, 9162-9167.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine enzyme is involved in skin differentiation and etiology of ichthyosiform diseases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid poor substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O
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 ?
(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
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 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O the former being a isomer of hepoxilin A3, ration of products is 2:1 ?
(5Z,8Z,11E,13Z,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoic acid poor substrate Homo sapiens 14,15-hepoxilin A3 + 14,15-hepoxilin B3 + H2O
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 ?
(8R)-hydroperoxy-(9Z,12Z)-octadecadienoic acid poor substrate Homo sapiens (7S,8S)-dihydroxy-(9Z,12Z)-octadecadienoic acid + H2O
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 ?