Literature summary for 4.2.1.91 extracted from

Corea, O.R.; Ki, C.; Cardenas, C.L.; Kim, S.J.; Brewer, S.E.; Patten, A.M.; Davin, L.B.; Lewis, N.G.
Arogenate dehydratase isoenzymes profoundly and differentially modulate carbon flux into lignins (2012), J. Biol. Chem., 287, 11446-11459.

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Cloned(Commentary)

Cloned (Comment)	Organism
genes adt1-adt6, complementation of the adt5 KO line with ADT5 gene expression under the control of its native promoter or the cauliflower mosaic virus 35S promoter	Arabidopsis thaliana

Protein Variants

Protein Variants	Comment	Organism
additional information	homozygous T-DNA insertion lines are generated for five of the six ADT isozymes and used to generate double, triple, and quadruple knockout mutants in different combinations. The various mutants so obtained give phenotypes with profound but distinct reductions in lignin amounts, encompassing a range spanning from near wild-type levels to reductions of up to about 68%. In the various KO mutants, there are also marked changes in guaiacyl:syringyl ratios ranging from 3:1 to 1:1, respectively, due to differential carbon flux into vascular bundles versus that into fiber cells	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
chloroplast	-	Arabidopsis thaliana	9507	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-arogenate	Arabidopsis thaliana	-	L-phenylalanine + H2O + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	six isozymes encoded by genes adt1-adt6	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
stem	expression patterns in of isozymes ADT4 and ADT5, histochemic analysis of wild-type and knockout mutant lines, overview	Arabidopsis thaliana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-arogenate	-	Arabidopsis thaliana	L-phenylalanine + H2O + CO2	-	?

Synonyms

Synonyms	Comment	Organism
AdT	-	Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Arabidopsis thaliana

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Arabidopsis thaliana

General Information

General Information	Comment	Organism
malfunction	phenotypes of adt isozyme knockout mutants, overview	Arabidopsis thaliana

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Release 2023.1 (January 2023)