Literature summary for 4.2.1.75 extracted from

Clavero, S.; Bishop, D.F.; Haskins, M.E.; Giger, U.; Kauppinen, R.; Desnick, R.J.
Feline acute intermittent porphyria: a phenocopy masquerading as an erythropoietic porphyria due to dominant and recessive hydroxymethylbilane synthase mutations (2010), Hum. Mol. Genet., 19, 584-596.

Search for more literature for 4.2.1.75

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Felis catus	-
liver	-	Felis catus	-
spleen	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hydroxymethylbilane	-	Felis catus	uroporphyrinogen III + H2O	-	?

Synonyms

Synonyms	Comment	Organism
URO-synthase	-	Felis catus
uroporphyrinogen-III-synthase	-	Felis catus

Expression

Organism	Comment	Expression
Felis catus	the hepatic and splenic URO-synthase activities are normal or elevated (1-1.6fold) compared with age and sex-matched feline control activities in the dominantly inherited acute intermittent porphyria lines	up

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Release 2023.1 (January 2023)