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Literature summary for 4.2.1.75 extracted from

  • Vargas, P.D.; Furuyama, K.; Sassa, S.; Shibahara, S.
    Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway (2008), FEBS J., 275, 5947-5959.
    View publication on PubMed
Search for more literature for 4.2.1.75

Cloned(Commentary)

Cloned (Comment) Organism
semi-quantitative real-time PCR analysis of ubiquitous and erythroid-specific UROS mRNAs, expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hydroxymethylbilane Homo sapiens intramolecular rearrangement of the d-pyrrole group and ring closure uroporphyrinogen III + H2O
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 ?
additional information Homo sapiens hydroxymethylbilane synthase and uroporphyrinogen III synthase catalyze two consecutive reactions, the third and fourth step, in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively. Hydroxymethylbilane synthase, 2.5.1.61, and uroporphyrinogen III synthase may function independently and sequentially with hydroxymethylbilane as a free intermediate, heme biosynthetic pathway, overview. Hypoxia downregulates UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia. Deferoxamine, cobalt chloride, or hypoxia downregulate UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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K-562 cell erythroleukemia cells Homo sapiens
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liver
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 Homo sapiens
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YN-1 cell erythroleukemia cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hydroxymethylbilane intramolecular rearrangement of the d-pyrrole group and ring closure Homo sapiens uroporphyrinogen III + H2O
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 ?
additional information hydroxymethylbilane synthase and uroporphyrinogen III synthase catalyze two consecutive reactions, the third and fourth step, in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively. Hydroxymethylbilane synthase, 2.5.1.61, and uroporphyrinogen III synthase may function independently and sequentially with hydroxymethylbilane as a free intermediate, heme biosynthetic pathway, overview. Hypoxia downregulates UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia. Deferoxamine, cobalt chloride, or hypoxia downregulate UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
hydroxymethylbilane hydrolyase, cyclizing
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 Homo sapiens
Uroporphyrinogen III synthase
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 Homo sapiens
UROS
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 Homo sapiens