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Literature summary for 4.2.1.70 extracted from
- Biosynthesis of pseudouridine in the in vitro transcribed tRNATyr precursor (1977), FEBS Lett., 77, 75-82.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Salmonella enterica subsp. enterica serovar Typhimurium | pseudouridylate synthetase I is responsible for the biosynthesis of pseudouridine in the anticodon region of several tRNA species | ? | - |
? |  |
| additional information | Salmonella enterica subsp. enterica serovar Typhimurium | pseudouridylate synthetase II is responsible for the biosynthesis of pseudouridine in the TpsiCG loop of every tRNA molecule | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
TA265 (wild-type strain of LT-2) | - |
| Salmonella enterica subsp. enterica serovar Typhimurium | - |
TA253 (carrying the hisT 1504 mutation) | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| pseudouridylate synthetase I, partial | Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | pseudouridylate synthetase I is responsible for the biosynthesis of pseudouridine in the anticodon region of several tRNA species | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| additional information | pseudouridylate synthetase II is responsible for the biosynthesis of pseudouridine in the TpsiCG loop of every tRNA molecule | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| uracil + D-ribose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | pseudouridine 5'-phosphate + H2O | - |
? | |
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