Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.30 extracted from

  • Poppe, L.; Hull, W.E.; Nitsche, R.; Graf, T.; Stupperich, E.; Retey, J.
    (Hydroxyalkyl)cob(III)alamins as competitive inhibitors in coenzyme B12-dependent enzymic reactions. 1H-NMR structure analysis and kinetic studies with glycerol dehydratase and diol dehydratase (1999), Helv. Chim. Acta, 82, 1250-1265.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
(2,3-dihydroxypropyl)cobalamin competes with coenzyme B12 Klebsiella pneumoniae
Cobeta-2,3-dihydroxypropyl-[1'-O-(4-tolyl)cobamide] moderate inhibitor Klebsiella pneumoniae
HO-(CH2)n-cobalamin chain lengths of n=2-5, short chains are more effective Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerol
-
Klebsiella pneumoniae 3-hydroxypropanal + H2O
-
?

Cofactor

Cofactor Comment Organism Structure
coenzyme B12
-
Klebsiella pneumoniae