Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GdrA | GdrA-GdrB complex reactivates the enzyme in the presence of ATP, Mg2+ and adenosylcobalamin, the reactivating factor mediates ATP-dependent exchange of the enzyme-bound, adenine-lacking cobalamin, for free adenosylcobalamin, an adenine-containing cobalamin, through intermediary formation of apoenzyme in the presence of ATP and Mg2+ | Klebsiella pneumoniae | |
GdrA | GdrA-GdrB complex reactivates the enzyme in the presence of ATP, Mg2+ and adenosylcobalamin, the reactivating factor mediates ATP-dependent exchange of the enzyme-bound, adenine-lacking cobalamin, for free adenosylcobalamin, an adenine-containing cobalamin, through intermediary formation of apoenzyme in the presence of ATP and Mg2+ | Klebsiella oxytoca | |
GdrB | GdrA-GdrB complex reactivates the enzyme in the presence of ATP, Mg2+ and adenosylcobalamin, the reactivating factor mediates ATP-dependent exchange of the enzyme-bound, adenine-lacking cobalamin, for free adenosylcobalamin, an adenine-containing cobalamin, through intermediary formation of apoenzyme in the presence of ATP and Mg2+ | Klebsiella pneumoniae | |
GdrB | GdrA-GdrB complex reactivates the enzyme in the presence of ATP, Mg2+ and adenosylcobalamin, the reactivating factor mediates ATP-dependent exchange of the enzyme-bound, adenine-lacking cobalamin, for free adenosylcobalamin, an adenine-containing cobalamin, through intermediary formation of apoenzyme in the presence of ATP and Mg2+ | Klebsiella oxytoca |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycerol | irreversible cleavage of the Co-C bond, forming 5'-deoxyadenosine and an unknown cobalamin species. The unknown cobalamin species is converted very slowly to OH-cobalamin. The cobalamin species that is formed remains tightly bound to the enzyme, inactivating the enzyme irreversibly | Klebsiella oxytoca | |
glycerol | irreversible cleavage of the Co-C bond, forming 5'-deoxyadenosine and an unknown cobalamin species. The unknown cobalamin species is converted very slowly to OH-cobalamin. The cobalamin species that is formed remains tightly bound to the enzyme, inactivating the enzyme irreversibly | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella oxytoca | - |
- |
- |
Klebsiella pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glycerol | - |
Klebsiella pneumoniae | 3-hydroxypropanal + H2O | - |
? | |
glycerol | - |
Klebsiella oxytoca | 3-hydroxypropanal + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
coenzyme B12 | - |
Klebsiella pneumoniae | |
coenzyme B12 | - |
Klebsiella oxytoca |