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Literature summary for 4.2.1.30 extracted from
- Biochemistry of coenzyme B-12-dependent glycerol and diol dehydratases and organization of the encoding genes (1999), FEMS Microbiol. Rev., 22, 553-566.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | - |
Lactobacillus sp. |  |
| NH4+ | activates | Klebsiella pneumoniae | |
| NH4+ | activates | Citrobacter freundii | |
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | 1,3-propanediol, starting material for producing plastics, from glycerol relies on the activity of glycerol or diol dehydratases | Klebsiella pneumoniae |
| synthesis | 1,3-propanediol, starting material for producing plastics, from glycerol relies on the activity of glycerol or diol dehydratases | Citrobacter freundii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glycerol | - |
Citrobacter freundii | |
| glycerol | - |
Klebsiella pneumoniae | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | - |
Lactobacillus sp. | |
| K+ | activates | Klebsiella pneumoniae | |
| K+ | activates | Citrobacter freundii | |
| Rb+ | - |
Lactobacillus sp. | |
| Rb+ | activates | Klebsiella pneumoniae | |
| Rb+ | activates | Citrobacter freundii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16121 | - |
alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid | Citrobacter freundii |
| 16722 | - |
alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid | Clostridium pasteurianum |
| 19549 | - |
alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid | Clostridium pasteurianum |
| 21487 | - |
alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid | Citrobacter freundii |
| 60433 | - |
alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid | Citrobacter freundii |
| 60813 | - |
alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid | Clostridium pasteurianum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | Klebsiella pneumoniae | - |
? | - |
? | |
| glycerol | Pantoea agglomerans | - |
? | - |
? | |
| glycerol | Clostridium pasteurianum | - |
? | - |
? | |
| glycerol | Levilactobacillus brevis | - |
? | - |
? | |
| glycerol | Lactobacillus sp. | - |
? | - |
? | |
| glycerol | Clostridium butyricum | - |
? | - |
? | |
| glycerol | Citrobacter freundii | - |
? | - |
? | |
| glycerol | Lentilactobacillus buchneri | - |
? | - |
? | |
| glycerol | Limosilactobacillus reuteri | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Citrobacter freundii | - |
- |
- |
| Clostridium butyricum | - |
- |
- |
| Clostridium pasteurianum | - |
- |
- |
| Klebsiella pneumoniae | - |
- |
- |
| Lactobacillus sp. | - |
- |
- |
| Lentilactobacillus buchneri | - |
- |
- |
| Levilactobacillus brevis | - |
- |
- |
| Limosilactobacillus reuteri | - |
- |
- |
| Pantoea agglomerans | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Klebsiella pneumoniae | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Pantoea agglomerans | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Clostridium pasteurianum | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Levilactobacillus brevis | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Lactobacillus sp. | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Clostridium butyricum | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Citrobacter freundii | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Lentilactobacillus buchneri | |
| glycerol = 3-hydroxypropanal + H2O | mechanism of enzyme reaction | Limosilactobacillus reuteri |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycerol | - |
Pantoea agglomerans | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Levilactobacillus brevis | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Lactobacillus sp. | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Clostridium butyricum | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Lentilactobacillus buchneri | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Limosilactobacillus reuteri | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | preferred substrate | Klebsiella pneumoniae | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | preferred substrate | Clostridium pasteurianum | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | preferred substrate | Citrobacter freundii | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | glycerol fermentation | Klebsiella pneumoniae | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | glycerol fermentation | Citrobacter freundii | 3-hydroxypropanal + H2O | 3-hydroxypropionaldehyde | ? | |
| glycerol | - |
Klebsiella pneumoniae | ? | - |
? | |
| glycerol | - |
Pantoea agglomerans | ? | - |
? | |
| glycerol | - |
Clostridium pasteurianum | ? | - |
? | |
| glycerol | - |
Levilactobacillus brevis | ? | - |
? | |
| glycerol | - |
Lactobacillus sp. | ? | - |
? | |
| glycerol | - |
Clostridium butyricum | ? | - |
? | |
| glycerol | - |
Citrobacter freundii | ? | - |
? | |
| glycerol | - |
Lentilactobacillus buchneri | ? | - |
? | |
| glycerol | - |
Limosilactobacillus reuteri | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | alpha2,beta2,gamma2, 2 * 60433 + 2 * 21487 + 2 * 16121, calculation from sequence of amino acid | Citrobacter freundii |
| hexamer | alpha2,beta2,gamma2, 2 * 60813 + 2 * 19549 + 2 * 16722, calculation from sequence of amino acid | Clostridium pasteurianum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Klebsiella pneumoniae | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Pantoea agglomerans | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Clostridium pasteurianum | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Levilactobacillus brevis | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Lactobacillus sp. | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Citrobacter freundii | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Lentilactobacillus buchneri | |
| 5,6-Dimethylbenzimidazolylcobamide | coenzyme required | Limosilactobacillus reuteri | |
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