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Literature summary for 4.2.1.3 extracted from

  • Degu, A.; Hatew, B.; Nunes-Nesi, A.; Shlizerman, L.; Zur, N.; Katz, E.; Fernie, A.R.; Blumwald, E.; Sadka, A.
    Inhibition of aconitase in Citrus fruit callus results in a metabolic shift towards amino acid biosynthesis (2011), Planta, 234, 501-513.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
citramalate an endogenous compound of fruit pulp, is a competitive endogenous inhibitor of citrus aconitase, it significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level Citrus limon
Oxalomalate significantly increases citrate content and reduces the enzyme's activity, while slightly inducing its protein level. Specific activities of amino acid-metabolizing enzymes are induced in oxalomalate-treated callus cells, overview Citrus limon

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol soluble isozyme Citrus limon 5829
-
mitochondrion mitochondrial isozyme Citrus limon 5739
-

Organism

Organism UniProt Comment Textmining
Citrus limon
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
callus from fruit juice cells Citrus limon
-
fruit
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Citrus limon
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Expression

Organism Comment Expression
Citrus limon citramalate significantly increases citrate content and reduces the mitochondrial isozyme activity, while slightly inducing its protein level, oxalomalate also slightly upregulates the enzyme up

General Information

General Information Comment Organism
physiological function the increase in citrate, caused by aconitase inhibition, induces amino acid synthesis and the gamma-aminobutyrate shunt, in accordance with the suggested fate of citrate during the acid decline stage in citrus fruit Citrus limon