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Literature summary for 4.2.1.3 extracted from

  • Maity, P.; Bindu, S.; Dey, S.; Goyal, M.; Alam, A.; Pal, C.; Mitra, K.; Bandyopadhyay, U.
    Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation (2009), J. Biol. Chem., 284, 3058-3068.
    View publication on PubMed
Search for more literature for 4.2.1.3

Inhibitors

Inhibitors Comment Organism Structure
indomethacin a non-steroidal anti-inflammatory drug, carbonylation of aconitase and release of iron along with the loss of activity in vivo after indomethacin treatment, activation of mitochondrial death pathway by indomethacin, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ mitochondrial aconitase contains iron-sulfur cluster Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
partially, isolation of mitochondria Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
gastric mucosa
-
 Rattus norvegicus
-
stomach
-
 Rattus norvegicus
-

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus