Literature summary for 4.2.1.3 extracted from

Dupuy, J.; Volbeda, A.; Carpentier, P.; Darnault, C.; Moulis, J.; Fontecilla-Camps, J.C.
Crystal structure of human iron regulatory protein 1 as cytosolic aconitase (2006), Structure, 14, 129-139.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
aconitase form of bifunctional enzyme, evaluation of model for iron regulatory form of enzyme and its binding to iron-responsive elements	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	under iron-replete conditions, enzyme binds a [4Fe-4S] cluster und functions as cytosolic aconitase. Under iron shortage, enzyme is involved in translational control as an iron regulatory protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P21399	bifunctional iron regulatory protein and cytosolic acontiatse	-

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Release 2023.1 (January 2023)