Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.3 extracted from

  • Andreeshcheva, E.M.; Popova, T.N.; Artyukhov, V.G.; Matasova, L.V.
    Free radical oxidation and catalytic activity of aconitate hydratase in rat liver under normal conditions and during toxic hepatitis (2004), Bull. Exp. Biol. Med., 137, 352-354.
    View publication on PubMed
Search for more literature for 4.2.1.3

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ activates the enzyme under normal conditions and in animals with toxic hepatitis. The stimulatory effect of Fe2+ in concentrations below 1 mM is less pronounced than in animals with toxic hepatitis Rattus rattus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus rattus toxic hepatitis is accompanied by inactivation of aconitate hydratase. Inhibition of the enzyme probably contributes to intracellular accumulation of citrate and inhibition of the Fenton reaction ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus rattus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver under normal conditions and during toxic hepatitis. Toxic hepatitis is accompanied by inactivation of aconitate hydratase Rattus rattus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information toxic hepatitis is accompanied by inactivation of aconitate hydratase. Inhibition of the enzyme probably contributes to intracellular accumulation of citrate and inhibition of the Fenton reaction Rattus rattus ?
-
 ?