Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | activates the enzyme under normal conditions and in animals with toxic hepatitis. The stimulatory effect of Fe2+ in concentrations below 1 mM is less pronounced than in animals with toxic hepatitis | Rattus rattus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus rattus | toxic hepatitis is accompanied by inactivation of aconitate hydratase. Inhibition of the enzyme probably contributes to intracellular accumulation of citrate and inhibition of the Fenton reaction | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus rattus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | under normal conditions and during toxic hepatitis. Toxic hepatitis is accompanied by inactivation of aconitate hydratase | Rattus rattus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | toxic hepatitis is accompanied by inactivation of aconitate hydratase. Inhibition of the enzyme probably contributes to intracellular accumulation of citrate and inhibition of the Fenton reaction | Rattus rattus | ? | - |
? |