Literature summary for 4.2.1.28 extracted from

Toraya, T.; Shirakashi, T.; Kosuga, T.; Fukui, S.
Substrate specificity of coenzyme B12-dependent diol dehydrase: glycerol as both a good substrate and a potent inactivator (1976), Biochem. Biophys. Res. Commun., 69, 475-480.

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Inhibitors

Inhibitors	Comment	Organism	Structure
glycerol	-	Klebsiella pneumoniae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.18	-	1,2-propanediol	both cytosolic and membrane associated enzymes	Klebsiella pneumoniae
0.64	-	2,3-Butanediol	-	Klebsiella pneumoniae
1.08	-	1,2-ethanediol	both cytosolic and membrane associated enzymes	Klebsiella pneumoniae
1.54	-	glycerol	cytosolic and membrane-associated enzymes	Klebsiella pneumoniae

Organism

Organism	UniProt	Comment	Textmining
Klebsiella pneumoniae	-	formerly Aerobacter aerogenes	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1,2-butanediol	-	Klebsiella pneumoniae	butyraldehyde	-	?
1,2-ethanediol	-	Klebsiella pneumoniae	acetaldehyde	-	?
1,2-propanediol	-	Klebsiella pneumoniae	propanal	-	?
2,3-butanediol	-	Klebsiella pneumoniae	methyl ethyl ketone	-	?
glycerol	-	Klebsiella pneumoniae	beta-hydroxypropionaldehyde	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
7.2	-	1,2-Butanediol	-	Klebsiella pneumoniae
15.1	-	2,3-Butanediol	-	Klebsiella pneumoniae
286	-	1,2-ethanediol	-	Klebsiella pneumoniae
337	-	1,2-propanediol	-	Klebsiella pneumoniae
371	-	glycerol	-	Klebsiella pneumoniae

Cofactor

Cofactor	Comment	Organism	Structure
cobamide	-	Klebsiella pneumoniae

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Release 2023.1 (January 2023)