Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in vivo iron reduction in rat blood has a negative correlation with the activity of delta-ALA-D, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | delta-ALA-D is a metalloenzyme requiring zinc for activation | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 5-aminolevulinate | Rattus norvegicus | - |
porphobilinogen + 2 H2O | - |
? | |
2 5-aminolevulinate | Rattus norvegicus Wistar | - |
porphobilinogen + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
animals infected with Trypanosoma evansi | - |
Rattus norvegicus Wistar | - |
animals infected with Trypanosoma evansi | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 5-aminolevulinate | - |
Rattus norvegicus | porphobilinogen + 2 H2O | - |
? | |
2 5-aminolevulinate | - |
Rattus norvegicus Wistar | porphobilinogen + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
delta-ALA-D | - |
Rattus norvegicus |
delta-aminolevulinate dehydratase | - |
Rattus norvegicus |
PBG-synthase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
39 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
assay at | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | infection with Trypanosoma evansi is associated with haematocrit, serum levels of iron and zinc and lipid peroxidation. Increased activity of delta-ALA-D in blood occurs in response to the anaemia in remission as heme synthesis is enhanced, iron reduction has a negative correlation with the activity of delta-ALA-D | Rattus norvegicus |