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Literature summary for 4.2.1.24 extracted from

  • Rocha, J.B.; Tuerlinckx, S.M.; Schetinger, M.R.; Folmer, V.
    Effect of Group 13 metals on porphobilinogen synthase in vitro (2004), Toxicol. Appl. Pharmacol., 200, 169-176.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Al3+ IC50: 0.319 mM, GSH has no protective effect Bos taurus
Ga3+ inhibits by competing with Zn2+, IC50: 0.442 mM, GSH has no protective effect, Zn2+ completely recovers inhibition Bos taurus
In3+ inhibits by competing with Zn2+, IC50: 0.298 mM, GSH reduces inhibition, DL-dithiothreitol has modest effect on inhibition, Zn2+ completely recovers inhibition Bos taurus
Tl3+ inhibits by direct oxidation of essential sulfhydryl groups, IC50: 0.0085 mM, DL-dithiothreitol restores completely enzyme activity inhibited by Tl3+, Zn2+ is unable to change inhibition Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Synonyms

Synonyms Comment Organism
PBGS
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0085
-
inhibits by direct oxidation of essential sulfhydryl groups, IC50: 0.0085 mM, DL-dithiothreitol restores completely enzyme activity inhibited by Tl3+, Zn2+ is unable to change inhibition Bos taurus Tl3+
0.298
-
inhibits by competing with Zn2+, IC50: 0.298 mM, GSH reduces inhibition, DL-dithiothreitol has modest effect on inhibition, Zn2+ completely recovers inhibition Bos taurus In3+
0.319
-
IC50: 0.319 mM, GSH has no protective effect Bos taurus Al3+
0.442
-
inhibits by competing with Zn2+, IC50: 0.442 mM, GSH has no protective effect, Zn2+ completely recovers inhibition Bos taurus Ga3+