Protein Variants | Comment | Organism |
---|---|---|
K195A | mutant enzyme with only 0.1% of the wild-type activity | Escherichia coli |
K195C | mutant enzyme with only 0.1% of the wild-type activity, 2-bromethylamine results in recovery of 10% of the wild-type activity | Escherichia coli |
K247A | inactive mutant enzyme | Escherichia coli |
K247C | inactive mutant enzyme, 2-bromethylamine results in recovery of 6% of the wild-type activity | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-chlorolevulinic acid | inactivation results fromthe initial formation of a Schiff base with lysine-247, followed by alkylation of lysine-195 by the resulting reactive chloroimide | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |