Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ethionine | i.e. 2-amino-4-(ethylthio)butyric acid, an methionine analogue, which is converted to S-adenosyl-ethionine in vivo and activates CBS, treatment increased liver CBS activity 4.0fold in wild-type mice | Mus musculus | |
S-adenosyl-L-methionine | - |
Mus musculus | |
S-adenosyl-L-methionine | - |
Rattus norvegicus | |
S-adenosyl-L-methionine | activates CBS by 13.6fold in Hep-G2 cell lysate | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | CBS activity in liver homogenates is reduced and plasma homocysteine levels are elevated in the CBS heterozygous knockout , CBS-/+ animals compared to wild-type littermate control mice. H2S is also significantly reduced by 30% and 46% compared to wild type in male and female CBS-/+ animals respectively | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | Mus musculus | - |
L-cystathionine + H2O | - |
? | |
L-serine + L-homocysteine | Homo sapiens | - |
L-cystathionine + H2O | - |
? | |
L-serine + L-homocysteine | Rattus norvegicus | - |
L-cystathionine + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | - |
Mus musculus | L-cystathionine + H2O | - |
? | |
L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? | |
L-serine + L-homocysteine | - |
Rattus norvegicus | L-cystathionine + H2O | - |
? | |
additional information | CBS also catalyze H2S production in vitro | Mus musculus | ? | - |
? | |
additional information | CBS also catalyze H2S production in vitro | Homo sapiens | ? | - |
? | |
additional information | CBS also catalyze H2S production in vitro | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CBS | - |
Mus musculus |
CBS | - |
Homo sapiens |
CBS | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Mus musculus |
8.5 | - |
assay at | Homo sapiens |
8.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus | |
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
additional information | increased immunoreactivity is evident in liver homogenates from mice treated with adenovirus carrying human CBS compared to mice treated with the Ad-lacZ virus | Homo sapiens |
additional information | increased immunoreactivity is evident in liver homogenates from mice treated with adenovirus carrying human CBS compared to mice treated with the Ad-lacZ virus. Overexpression of hCBS reduces homocysteine levels significantly by 5.3fold compared to Ad-lacZ treated mice | Mus musculus |
physiological function | CBS activity partially regulates endogenous H2S in mice. It contributes significantly to endogenous H2S production in mice, adenovirus-mediated overexpression of CBS in the liver significantly increases circulating levels of H2S, whereas CBS deficiency results in reduced levels. irculating H2S levels are increased by pharmacological activation of CBS in vivo; i.e. in the presence of the endogenous activator | Mus musculus |