Literature summary for 4.2.1.22 extracted from

Kim, J.; Hong, S.J.; Park, J.H.; Park, S.Y.; Kim, S.W.; Cho, E.Y.; Do, I.G.; Joh, J.W.; Kim, D.S.
Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis (2009), Oncol. Rep., 21, 1449-1454.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CBS	-	Homo sapiens
cystathionine beta-synthase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression level of CBS in 120 hepatocellular carcinoma specimens evaluated by RT-PCR is markedly lower than in surrounding non-cancerous liver. Reduced CBS expression is significantly correlated with high tumor stage. A survival analysis shows that a significantly shorter overall survival time is observed in patients with reduced CBS expression	down

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Release 2023.1 (January 2023)