Literature summary for 4.2.1.22 extracted from

Chao, W.H.; Reynolds, R.D.
Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice (2009), Nutr. Res., 29, 794-801.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CBS	-	Mus musculus
cystathionine beta-synthase	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	in hemizygous (+/-) CBS knockout mice the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA	up

General Information

General Information	Comment	Organism
malfunction	hemizygous (+/-) CBS knockout mice are analysed: Significantly higher plasma total homocysteine concentrations occurr in the CBS (+/-) mice than in wild-type cohorts. Female mice of both genotypes have significantly higher plasma total homocysteine concentrations and lower relative CBS mRNA levels than did male mice. During vitamin B6 deficiency, plasma total homocysteine concentrations are significantly elevated. CBS (+/-) mice have a lower plasma cholesterol concentration, and during a taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice are reduced only 13%	Mus musculus

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Release 2023.1 (January 2023)