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Literature summary for 4.2.1.22 extracted from

  • Ganapathy, P.S.; Moister, B.; Roon, P.; Mysona, B.A.; Duplantier, J.; Dun, Y.; Moister, T.K.; Farley, M.J.; Prasad, P.D.; Liu, K.; Smith, S.B.
    Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse (2009), Invest. Ophthalmol. Vis. Sci., 50, 4460-4470.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Subunits

Subunits Comment Organism
dimer
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 Mus musculus

Synonyms

Synonyms Comment Organism
CBS
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 Mus musculus
cystathionine beta-synthase
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 Mus musculus

General Information

General Information Comment Organism
malfunction the effects of endogenous elevation of homocysteine on the retina using the cystathionine beta-synthase mutant mouse is determined. Increased retinal homocysteine alters inner and outer retinal layers in cbs homozygous mice and older cbs heterozygous mice, and it primarily affects the cells of the ganglion cell layer in younger heterozygous mice. Elevated retinal homocysteine alters expression of genes involved in endoplasmic reticular stress, N-methyl-D-aspartate (NMDA) receptor activation, cell cycle, and apoptosis Mus musculus