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Literature summary for 4.2.1.22 extracted from

  • Ozaki, S.; Doi, M.; Migita, C.T.
    Modulation of cystathionine beta-synthase activity by altering heme environment (2008), Chem. Lett., 37, 208-209.
No PubMed abstract available
Search for more literature for 4.2.1.22

Cloned(Commentary)

Cloned (Comment) Organism
the truncated human CBS enzyme consisting of residue 1-397 is expressed in the glutathione S-transferase fusion expression system Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the alternation of heme environment inactivates the enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-serine + L-homocysteine
-
 Homo sapiens L-cystathionine + H2O
-
 ?

Subunits

Subunits Comment Organism
homodimer truncated CBS, X-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
CBS
-
 Homo sapiens
CBS424 inactive form of CBS Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme the specific activity of the alkaline form is approximately 25% of that for the intact CBS enzyme when the heme iron is in the ferric state Homo sapiens
pyridoxal 5'-phosphate
-
 Homo sapiens