Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AdoMet | allosteric regulator, 1mol per mole of monomeric subunit activates the enzyme 2fold | Homo sapiens | |
additional information | oxidizing conditions increase the enzyme activity by 2fold | Mammalia |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
C272A | spectroscopic properties similar to wild-type enzyme | Mammalia |
C275S | spectroscopic properties similar to wild-type enzyme | Mammalia |
D444N | high level of enzyme activity | Homo sapiens |
additional information | C-terminal regulatory domain deletion leads to formation of highly active dimeric enzyme | Homo sapiens |
additional information | C-terminal regulatory domain deletion leads to formation of highly active dimeric enzyme | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Dithionite | 2fold decrease in enzyme activity due to altered oxidation state of the heme | Mammalia | |
titanium citrate | 2fold decrease in enzyme activity due to altered oxidation state of the heme | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mammalia | first step in transsulfuration pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-serine + L-homocysteine = L-cystathionine + H2O | mechanism | Homo sapiens | |
L-serine + L-homocysteine = L-cystathionine + H2O | mechanism | Saccharomyces cerevisiae |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Serine + homocysteine | - |
Mammalia | Cystathionine + H2O | - |
r | |
L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
r | |
L-Serine + homocysteine | - |
Saccharomyces cerevisiae | Cystathionine + H2O | - |
r | |
additional information | first step in transsulfuration pathway | Mammalia | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | after deletion of the C-terminal regulatory domain | Homo sapiens |
dimer | after deletion of the C-terminal regulatory domain | Saccharomyces cerevisiae |
octamer | homooctamer | Saccharomyces cerevisiae |
tetramer | alpha4 homotetramer | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | iron protoporphyrin IX | Mammalia | |
pyridoxal 5'-phosphate | dependent | Mammalia | |
pyridoxal 5'-phosphate | dependent | Homo sapiens | |
pyridoxal 5'-phosphate | dependent | Saccharomyces cerevisiae |