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Literature summary for 4.2.1.22 extracted from

  • Banerjee, R.; Evande, R.; Kabil, O.; Ojha, S.; Taoka, S.
    Reaction mechanism and regulation of cystathionine beta-synthase (2003), Biochim. Biophys. Acta, 1647, 30-35.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
AdoMet allosteric regulator, 1mol per mole of monomeric subunit activates the enzyme 2fold Homo sapiens
additional information oxidizing conditions increase the enzyme activity by 2fold Mammalia

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
-
Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
C272A spectroscopic properties similar to wild-type enzyme Mammalia
C275S spectroscopic properties similar to wild-type enzyme Mammalia
D444N high level of enzyme activity Homo sapiens
additional information C-terminal regulatory domain deletion leads to formation of highly active dimeric enzyme Homo sapiens
additional information C-terminal regulatory domain deletion leads to formation of highly active dimeric enzyme Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
Dithionite 2fold decrease in enzyme activity due to altered oxidation state of the heme Mammalia
titanium citrate 2fold decrease in enzyme activity due to altered oxidation state of the heme Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia first step in transsulfuration pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mammalia
-
-
-
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-serine + L-homocysteine = L-cystathionine + H2O mechanism Homo sapiens
L-serine + L-homocysteine = L-cystathionine + H2O mechanism Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Serine + homocysteine
-
Mammalia Cystathionine + H2O
-
r
L-Serine + homocysteine
-
Homo sapiens Cystathionine + H2O
-
r
L-Serine + homocysteine
-
Saccharomyces cerevisiae Cystathionine + H2O
-
r
additional information first step in transsulfuration pathway Mammalia ?
-
?

Subunits

Subunits Comment Organism
dimer after deletion of the C-terminal regulatory domain Homo sapiens
dimer after deletion of the C-terminal regulatory domain Saccharomyces cerevisiae
octamer homooctamer Saccharomyces cerevisiae
tetramer alpha4 homotetramer Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme iron protoporphyrin IX Mammalia
pyridoxal 5'-phosphate dependent Mammalia
pyridoxal 5'-phosphate dependent Homo sapiens
pyridoxal 5'-phosphate dependent Saccharomyces cerevisiae