Activating Compound | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | activates full length enzyme, but not the truncated core, 4 S-adenosyl-L-methionine molecules per tetramer | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | CBSdeltaC143, truncated catalytic core in which the C-terminal 143 amino acid residues are deleted, higher Km for the substrates | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
L-serine | pH 6.8, 37°C, full length enzyme after L-serine pre-treatment | Homo sapiens | |
5 | - |
homocysteine | pH 6.8, 37°C, full length enzyme after L-serine pre-treatment | Homo sapiens | |
5.5 | - |
L-serine | pH 6.8, 37°C, full length enzyme after homocysteine pre-treatment | Homo sapiens | |
9.7 | - |
homocysteine | pH 6.8, 37°C, deltaC143 mutant after L-serine pre-treatment | Homo sapiens | |
14 | - |
L-serine | pH 6.8, 37°C, deltaC143 mutant after homocysteine pre-treatment | Homo sapiens | |
15 | - |
homocysteine | pH 6.8, 37°C, full length enzyme after homocysteine pre-treatment | Homo sapiens | |
18 | - |
L-serine | pH 6.8, 37°C, deltaC143 mutant after L-serine pre-treatment | Homo sapiens | |
67 | - |
homocysteine | pH 6.8, 37°C, deltaC143 mutant after homocysteine pre-treatment | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
CBSdeltaC143 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Serine + homocysteine | - |
Homo sapiens | Cystathionine + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | truncated catalytic core | Homo sapiens |
tetramer | native enzyme | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
19 | - |
L-serine | pH 6.8, 37°C, deltaC143 mutant after L-serine pre-treatment | Homo sapiens | |
21 | - |
L-serine | pH 6.8, 37°C, full length enzyme after L-serine pre-treatment | Homo sapiens | |
39 | - |
L-serine | pH 6.8, 37°C, full length enzyme after homocysteine pre-treatment | Homo sapiens | |
45 | - |
L-serine | pH 6.8, 37°C, deltaC143 mutant after homocysteine pre-treatment | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Homo sapiens |