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Literature summary for 4.2.1.22 extracted from

  • Janosik, M.; Meier, M.; Kery, V.; Oliveriusova, J.; Burkhard, P.; Kraus, J.P.
    Crystallization and preliminary x-ray diffraction analysis of the active core of human recombinant cystathionine beta-synthase: an enzyme involved in vascular disease (2001), Acta Crystallogr. Sect. D, D57, 289-291.
    View publication on PubMed

Application

Application Comment Organism
medicine inherited deficiency leads to homocystinuria, an autosomal recessivlely inherited disease of sulfur metabolism Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
truncated form fused with glutathione S-transferase Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
with heme and pyridoxal 5'-phosphate, hanging drop vapor diffusion method Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Serine + homocysteine
-
Homo sapiens Cystathionine + H2O
-
?

Subunits

Subunits Comment Organism
dimer truncated form of the enzyme Homo sapiens
oligomer full length subunits for tetramers and higher oligomers Homo sapiens
tetramer full length subunits for tetramers and higher oligomers Homo sapiens