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Literature summary for 4.2.1.2 extracted from

  • Alam, N.A.; Olpin, S.; Rowan, A.; Kelsell, D.; Leigh, I.M.; Tomlinson, I.P.; Weaver, T.
    Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer (2005), J. Mol. Diagn., 7, 437-443.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens all missense mutations of fumarate hydratase associating with MCUL/hereditary leiomyomatosis and renal cell cancer show diminished fumarate hydratase enzymatic. It is suggested that the tumor suppressor role of fumarate hydratase may relate to its enzymatic function ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
renal cell carcinoma cell all missense mutations of fumarate hydratase associating with MCUL/hereditary leiomyomatosis and renal cell cancer show diminished fumarate hydratase enzymatic Homo sapiens
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uterine leiomyoma cell all missense mutations of fumarate hydratase associating with MCUL/hereditary leiomyomatosis and renal cell cancer show diminished fumarate hydratase enzymatic Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information all missense mutations of fumarate hydratase associating with MCUL/hereditary leiomyomatosis and renal cell cancer show diminished fumarate hydratase enzymatic. It is suggested that the tumor suppressor role of fumarate hydratase may relate to its enzymatic function Homo sapiens ?
-
?