Literature summary for 4.2.1.159 extracted from

Hong L, H.L.; Zhao Z, Z.Z.; Liu H.-W, L.H.
Characterization of SpnQ from the spinosyn biosynthetic pathway of Saccharopolyspora spinosa: Mechanistic and evolutionary implications for C-3 deoxygenation in deoxysugar biosynthesis (2006), J. Am. Chem. Soc., 128, 14262-14263.

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Organism

Organism	UniProt	Comment	Textmining
Saccharopolyspora spinosa	Q9ALN6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose	-	Saccharopolyspora spinosa	dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O	enzymes SpnO and SpnN are the 2,3-dehydratase and 3-ketoreductase, which together catalyze the conversion of dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose to 4-dehydro-2,6-dideoxy-D-glucose	?

Synonyms

Synonyms	Comment	Organism
spnO	-	Saccharopolyspora spinosa

General Information

General Information	Comment	Organism
physiological function	in forosamine biosynthesis, enzymes SpnO and SpnN function as a 2,3-dehydrase and a 3-ketoreductase, respectively. The two enzymes act sequentially to catalyze C-2 deoxygenation of TDP-4-dehydro-6-deoxy-D-glucose to form the SpnQ substrate, TDP-4-dehydro-2,6-dideoxy-D-glucose	Saccharopolyspora spinosa

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Release 2023.1 (January 2023)