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Literature summary for 4.2.1.152 extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Marnett, L.J.; Brash, A.R.
    The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase (2003), Proc. Natl. Acad. Sci. USA, 100, 9162-9167.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
nordihydroguaiaretic acid submicromolar concentrations of nordihydroguaiaretic acid cause a dose-dependent increase in reaction rate 83-4fold with 12R-HPETE and up to 6fold with 15S-HPETE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(12R)-hydroperoxyeicosatetraenoic acid Homo sapiens preferred substrate (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(12R)-hydroperoxyeicosatetraenoic acid preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 ratio ?
(12R)-hydroperoxyeicosatetraenoic acid preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid 2:1 product ratio ?
(12S)-hydroperoxyeicosatetraenoic acid
-
 Homo sapiens (10R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,8Z,14Z)-trienoic acid + (8R)-hydroxy-(11S,12S)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + 12-oxoeicosatetraenoic acid
-
 ?
(15S)-hydroperoxyeicosatetraenoic acid
-
 Homo sapiens (13R)-hydroxy-(14S,15S)-epoxyeicosa-(5Z,8Z,11Z)-trienoic acid + 12-oxoeicosatetraenoic acid
-
 ?
additional information linoleic, arachidonic, and eicosapentaenoic acids, the methyl esters of arachidonic acid and linoleic acid, arachidonyl phosphatidylcholine, anandamide, and the cholesteryl ester of arachidonic acid are no substrates Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
eLOX3
-
 Homo sapiens
epidermal LOX type 3
-
 Homo sapiens