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Literature summary for 4.2.1.149 extracted from

  • Engemann, C.; Elssner, T.; Pfeifer, S.; Krumbholz, C.; Maier, T.; Kleber, H.P.
    Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp. (2005), Arch. Microbiol., 183, 176-189.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Proteus sp.

Inhibitors

Inhibitors Comment Organism Structure
acetoacetyl-CoA 0.1 mM, 25% inhibition Proteus sp.
acetyl-CoA 0.1 mM, 23% inhibition Proteus sp.
butyryl-CoA 0.1 mM, 29% inhibition Proteus sp.
CoA 0.1 mM, 29% inhibition Proteus sp.
decanoyl-CoA 0.1 mM, 79% inhibition Proteus sp.
gamma-butyrobetainyl-CoA 0.1 mM, 27% inhibition, competitive inhibitor Proteus sp.
hexanoyl-CoA 0.1 mM, 43% inhibition Proteus sp.
palmitoyl-CoA 0.01 mM, 87% inhibition Proteus sp.
succinyl-CoA 0.1 mM, 22% inhibition Proteus sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.043
-
(E)-4-(trimethylammonio)but-2-enoyl-CoA 37°C, pH 7.5 Proteus sp.
0.52
-
crotonyl-CoA 37°C, pH 7.5 Proteus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
3 * 40000, SDS-PAGE Proteus sp.
85700
-
gel filtration Proteus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O Proteus sp. the enzyme is involved in carnitine metabolism L-carnitinyl-CoA
-
r
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O Proteus sp. LE138 the enzyme is involved in carnitine metabolism L-carnitinyl-CoA
-
r

Organism

Organism UniProt Comment Textmining
Proteus sp. Q8GB17
-
-
Proteus sp. LE138 Q8GB17
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Proteus sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6088
-
37°C, pH 7.5 Proteus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O the enzyme is involved in carnitine metabolism Proteus sp. L-carnitinyl-CoA
-
r
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O (E)-4-(trimethylammonio)but-2-enoyl-CoA i.e. crotonobetainyl-CoA Proteus sp. L-carnitinyl-CoA L-carnitinyl-CoA i.e. (3R)-3-hydroxy-4-(trimethylammonio)butanoyl-CoA r
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O the enzyme is involved in carnitine metabolism Proteus sp. LE138 L-carnitinyl-CoA
-
r
(E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O (E)-4-(trimethylammonio)but-2-enoyl-CoA i.e. crotonobetainyl-CoA Proteus sp. LE138 L-carnitinyl-CoA L-carnitinyl-CoA i.e. (3R)-3-hydroxy-4-(trimethylammonio)butanoyl-CoA r
crotonyl-CoA + H2O crotonyl-CoA is hydrated with low efficiency than (E)-4-(trimethylammonio)but-2-enoyl-CoA Proteus sp. ?
-
?
crotonyl-CoA + H2O crotonyl-CoA is hydrated with low efficiency than (E)-4-(trimethylammonio)but-2-enoyl-CoA Proteus sp. LE138 ?
-
?

Subunits

Subunits Comment Organism
homotrimer 3 * 40000, SDS-PAGE Proteus sp.

Synonyms

Synonyms Comment Organism
CaiD
-
Proteus sp.
L-carnityl-CoA dehydratase
-
Proteus sp.

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.068
-
gamma-butyrobetainyl-CoA 37°C, pH 7.5 Proteus sp.

General Information

General Information Comment Organism
physiological function the enzyme is involved in carnitine metabolism Proteus sp.