Literature summary for 4.2.1.142 extracted from

Sakuno, E.; Wen, Y.; Hatabayashi, H.; Arai, H.; Aoki, C.; Yabe, K.; Nakajima, H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis (2005), Appl. Environ. Microbiol., 71, 2999-3006.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Pichia pastoris	Aspergillus parasiticus

Protein Variants

Protein Variants	Comment	Organism
additional information	truncation of the N-terminal 41-amino-acid region may not affect the substrate specificity	Aspergillus parasiticus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus parasiticus	Q12062	VBS	-
Aspergillus parasiticus NRRL 2999	Q12062	VBS	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-oxoaverantin	i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione	Aspergillus parasiticus	(2'S,5'S)-averufin + H2O	i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione	?
5'-oxoaverantin	i.e. 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione	Aspergillus parasiticus NRRL 2999	(2'S,5'S)-averufin + H2O	i.e. 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione	?
additional information	in addition, enzyme catalyzes the conversion of versiconal to versicolorin B, reaction of EC 4.2.1.143, versicolorin B synthase	Aspergillus parasiticus	?	-	?
additional information	in addition, enzyme catalyzes the conversion of versiconal to versicolorin B, reaction of EC 4.2.1.143, versicolorin B synthase	Aspergillus parasiticus NRRL 2999	?	-	?

Synonyms

Synonyms	Comment	Organism
VBS	-	Aspergillus parasiticus
versicolorin B synthase	-	Aspergillus parasiticus

General Information

General Information	Comment	Organism
physiological function	enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour	Aspergillus parasiticus

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Release 2023.1 (January 2023)