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Literature summary for 4.2.1.130 extracted from
- DJ-1 family Maillard deglycases prevent acrylamide formation (2016), Biochem. Biophys. Res. Commun., 478, 1111-1116.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | activates the glyoxalase activity | Pyrococcus furiosus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyrococcus furiosus | Q51732 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-oxopropanal + H2O | i.e. methylglyoxal | Pyrococcus furiosus | (R)-lactate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glyoxalase III | - |
Pyrococcus furiosus |
| PfpI | - |
Pyrococcus furiosus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 85 | - |
assay at | Pyrococcus furiosus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Pyrococcus furiosus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme PfpI belongs to the PfpI/Hsp31/DJ-1 superfamily | Pyrococcus furiosus |
| physiological function | the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 72% by PfpI | Pyrococcus furiosus |
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Release 2023.1 (January 2023)
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