Literature summary for 4.2.1.12 extracted from

Gardner, P.R.; Fridovich, I.
Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase (1991), J. Biol. Chem., 266, 1478-1483.

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Inhibitors

Inhibitors	Comment	Organism	Structure
H2O2	the enzyme is much less sensitive to O2 or H2O2 than to O2-	Escherichia coli
O2	the enzyme is much less sensitive to O2 or H2O2 than to O2-	Escherichia coli
O2-	the O2--sensitive target site is proposed to be an iron-sulfur cluster which is readily destroyed by oxidation	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	enzyme contains iron-sulfur clusters	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Oxidation Stability

Oxidation Stability	Organism
F- stabilizes and blocks the efect of oxidants	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-phospho-D-gluconate	-	Escherichia coli	6-phospho-2-dehydro-3-deoxy-D-gluconate + H2O	-	?

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Release 2023.1 (January 2023)