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Literature summary for 4.2.1.115 extracted from

  • McNally, D.J.; Schoenhofen, I.C.; Houliston, R.S.; Khieu, N.H.; Whitfield, D.M.; Logan, S.M.; Jarrell, H.C.; Brisson, J.
    CMP-pseudaminic acid is a natural potent inhibitor of PseB, the first enzyme of the pseudaminic acid pathway in Campylobacter jejuni and Helicobacter pylori (2008), ChemMedChem, 3, 55-59.
    View publication on PubMed
Search for more literature for 4.2.1.115

Inhibitors

Inhibitors Comment Organism Structure
CMP-pseudaminic acid mapping of the dynamic interactions of the enzyme with the inhibitor, overview Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Helicobacter pylori dependence of O-linked flagellin glycosylation on PseB, cross-talk between the Pse and alpha-D-QuiNAc4NAc, i.e. 2,4-diacetamido-2,4,6-trideoxy-a-d-Glc, pathways via PseB ?
-
 ?
UDP-N-acetylglucosamine Helicobacter pylori the enzyme is required for pseudaminic acid biosynthesis, which is required for O-linked flagellin glycosylation UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information dependence of O-linked flagellin glycosylation on PseB, cross-talk between the Pse and alpha-D-QuiNAc4NAc, i.e. 2,4-diacetamido-2,4,6-trideoxy-a-d-Glc, pathways via PseB Helicobacter pylori ?
-
 ?
additional information PseB catalyzes an additional C5 epimerization forming UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hexos-4-ulose Helicobacter pylori ?
-
 ?
UDP-N-acetylglucosamine the enzyme is required for pseudaminic acid biosynthesis, which is required for O-linked flagellin glycosylation Helicobacter pylori UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
-
 ?
UDP-N-acetylglucosamine NMR reaction analysis, substrate binding at the active site, mapping of dynamic interactions of the enzyme with its ligand, molecular docking, overview Helicobacter pylori UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H2O
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 ?

Synonyms

Synonyms Comment Organism
4,6-dehydratase/5-epimerase
-
 Helicobacter pylori
PseB
-
 Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
 assay at Helicobacter pylori