Protein Variants | Comment | Organism |
---|---|---|
additional information | transient silencing of the enzyme in HeLa cells. Stable knockdown of the enzyme specifically affects growth in 5-methylthioadenosine and depletes intracellular levels of methionine | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required by the enzyme protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96GX9 | gene mtnB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
5'-methylthioribulose-1-phosphate dehydratase | - |
Homo sapiens |
APIP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme depletion specifically impairs the capacity of cells to grow in media where methionine is replaced by 5-methylthioadenosine. Knockdown of the enzyme specifically affects the recycling of methionine, and mutation of three potential phosphorylation sites does not affect the enzyme activity whereas mutation of the potential zinc binding site completely abrogates it | Homo sapiens |
metabolism | the enzyme catalyzes the dehydratase step in the methionine salvage pathway | Homo sapiens |
physiological function | the enzyme is involved in the methionine salvage pathway that recycles the sulfur-containing metabolite 5-methylthioadenosine to methionine | Homo sapiens |