Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis | |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Helicobacter pylori | |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | - |
Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
3-dehydroquinate | at pH 7.0, 25°C | Mycobacterium tuberculosis | |
0.48 | - |
3-dehydroquinate | at pH 7.0, 25°C | Helicobacter pylori |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | Q48255 | - |
- |
Mycobacterium tuberculosis | P9WPX7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WPX7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-dehydroquinate | - |
Helicobacter pylori | 3-dehydroshikimate + H2O | - |
r | |
3-dehydroquinate | - |
Mycobacterium tuberculosis | 3-dehydroshikimate + H2O | - |
r | |
3-dehydroquinate | - |
Mycobacterium tuberculosis H37Rv | 3-dehydroshikimate + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
DHQ2 | - |
Helicobacter pylori |
DHQ2 | - |
Mycobacterium tuberculosis |
Type II dehydroquinase | - |
Helicobacter pylori |
Type II dehydroquinase | - |
Mycobacterium tuberculosis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
3-dehydroquinate | at pH 7.0, 25°C | Helicobacter pylori | |
0.15 | - |
3-dehydroquinate | at pH 7.0, 25°C | Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000026 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.000028 | - |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.000047 | - |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.000056 | - |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.000074 | - |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.000089 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.00009 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.00009 | - |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.0001 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.0001 | - |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris·HCl | Mycobacterium tuberculosis | |
0.00016 | - |
(1R,2R,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00017 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00025 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00076 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.0009 | - |
(1R,2S,4S,5R)-2-(1-benzothiophen-5-yl)-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00097 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methylbenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00097 | - |
(1R,2S,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00118 | - |
(1R,2S,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.0014 | - |
(1R,2R,4S,5R)-2-benzyl-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.00142 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-2-(4-methoxybenzyl)-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.0017 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.00185 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HOAc | Mycobacterium tuberculosis | |
0.0026 | - |
(1R,2R,4S,5R)-2-[difluoro(pentafluorophenyl)methyl]-1,4,5-trihydroxy-3-oxocyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.0093 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.02 | - |
(1R,2R,4S,5R)-1,4,5-trihydroxy-3-oxo-2-propylcyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori | |
0.0215 | - |
(1R,2S,4S,5R)-1,4,5-trihydroxy-3-oxo-2-(prop-2-en-1-yl)cyclohexanecarboxylic acid | pH 7.0, 25°C, 50 mM Tris-HCl | Helicobacter pylori |