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Literature summary for 4.2.1.10 extracted from

  • Kleanthous, C.; Deka, R.; Davis, K.; Kelly, S.M.; Cooper, A.; Harding, S.E.; Price, N.C.; Hawkins, A.R.; Coggins, J.R.
    A comparison of the enzymological and biophysical properties of two distinct classes of dehydroquinase enzymes (1992), Biochem. J., 282, 687-695.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
guanidine hydrochloride, the type II enzyme from Aspergillus nidulans unfolds at concentrations of denaturant 4fold greater than type I enzyme from E. coli and through a series of discrete transitions, while the type I enzyme from E. coli unfolds in a single transition Escherichia coli
guanidine hydrochloride, the type II enzyme from Aspergillus nidulans unfolds at concentrations of denaturant 4fold greater than type I enzyme from E. coli and through a series of discrete transitions, while the type I enzyme from E. coli unfolds in a single transition Aspergillus nidulans

Inhibitors

Inhibitors Comment Organism Structure
diethyl dicarbonate
-
Aspergillus nidulans
diethyl dicarbonate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
3-dehydroquinate
-
Escherichia coli
0.15
-
3-dehydroquinate
-
Aspergillus nidulans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16505
-
12 * 16505 Aspergillus nidulans
27466
-
2 * 27466 Escherichia coli
44000 53000 sedimentation velocity determination and equilibrium sedimentation Escherichia coli
190000 200000 determination of sedimentation velocity and equilibrium sedimentation Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-dehydroquinate Aspergillus nidulans type II dehydroquinase is involved in the quinate pathway ?
-
?
3-dehydroquinate Escherichia coli type I dehydroquinase is involved in the biosynthetic shikimate pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
type II dehydroquinase
-
Escherichia coli
-
type I dehydroquinase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-dehydroquinate
-
Escherichia coli 3-dehydroshikimate + H2O
-
?
3-dehydroquinate
-
Aspergillus nidulans 3-dehydroshikimate + H2O
-
?
3-dehydroquinate type II dehydroquinase is involved in the quinate pathway Aspergillus nidulans ?
-
?
3-dehydroquinate type I dehydroquinase is involved in the biosynthetic shikimate pathway Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 27466 Escherichia coli
dodecamer 12 * 16505 Aspergillus nidulans

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
57
-
Tm: 57°C, irreversible thermal denaturation Escherichia coli
70
-
10 min, stable Aspergillus nidulans
70
-
10 min, not stable Escherichia coli
82
-
irreversible thermal denaturation involves at least three transitions. The first is a broad shoulder at approximately 82°C, the second is a shoarp doublet at 86°C and the final transition occurs at 95°C Aspergillus nidulans