Literature summary for 4.2.1.1 extracted from

Innocenti, A.; Zimmerman, S.; Ferry, J.G.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions (2004), Bioorg. Med. Chem. Lett., 14, 4563-4567.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Br-	-	Methanothermobacter thermautotrophicus
CN-	-	Methanothermobacter thermautotrophicus
CNO-	-	Methanothermobacter thermautotrophicus
CO32-	-	Methanothermobacter thermautotrophicus
HCO3-	-	Methanothermobacter thermautotrophicus
HS-	-	Methanothermobacter thermautotrophicus
HSO3-	-	Methanothermobacter thermautotrophicus
I-	-	Methanothermobacter thermautotrophicus
additional information	fluoride, chloride, and sulfate do not inhibit the enzyme appreciably	Methanothermobacter thermautotrophicus
N3-	-	Methanothermobacter thermautotrophicus
NO2-	-	Methanothermobacter thermautotrophicus
NO3-	-	Methanothermobacter thermautotrophicus
phenylarsonic acid	-	Methanothermobacter thermautotrophicus
phenylboronic acid	-	Methanothermobacter thermautotrophicus
SCN-	-	Methanothermobacter thermautotrophicus
sulfamic acid	-	Methanothermobacter thermautotrophicus
sulfamide	-	Methanothermobacter thermautotrophicus

Organism

Organism	UniProt	Comment	Textmining
Methanothermobacter thermautotrophicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Methanothermobacter thermautotrophicus	H2CO3	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
20	-	assay at	Methanothermobacter thermautotrophicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.2	-	phenylboronic acid	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.33	-	phenylarsonic acid	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.52	-	SCN-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.7	-	HS-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
7.8	-	NO3-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
9.6	-	CO32-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
11.2	-	CNO-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
13.2	-	I-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
27.8	-	CN-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
42.1	-	Br-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
44	-	sulfamic acid	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
44.8	-	NO2-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
44.9	-	HCO3-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
45.1	-	HSO3-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
55.7	-	N3-	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
103	-	sulfamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus

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Release 2023.1 (January 2023)