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Literature summary for 4.2.1.1 extracted from
- Catalytic activity of a zeta-class zinc and cadmium containing carbonic anhydrase. Compared work mechanisms (2011), Phys. Chem. Chem. Phys., 13, 3468-3477.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cd2+ | replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme | Methanosarcina thermophila |  |
| Cd2+ | replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme | Conticribra weissflogii | |
| Zn2+ | required for activity. Replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme | Methanosarcina thermophila | |
| Zn2+ | required for activity. Replacement of zinc ion with cadmium does not entail significant differences in the catalytic performance of the enzyme | Conticribra weissflogii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | Methanosarcina thermophila | - |
CO2 + H2O | - |
r | |
| H2CO3 | Conticribra weissflogii | - |
CO2 + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Conticribra weissflogii | - |
- |
- |
| Methanosarcina thermophila | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| H2CO3 = CO2 + H2O | reaction mechanism, model of the active site designed on the basis of the X-ray crystal structure, proposed for both metal ions similar reaction pathways consisting in the nucleophilic attack by the metal bound hydroxide to the carbon dioxide with bicarbonate formation, in a next internal rotation of this last fragment, and then in the formation of a species ready for the product removal, overview | Methanosarcina thermophila | |
| H2CO3 = CO2 + H2O | reaction mechanism, model of the active site designed on the basis of the X-ray crystal structure, proposed for both metal ions similar reaction pathways consisting in the nucleophilic attack by the metal bound hydroxide to the carbon dioxide with bicarbonate formation, in a next internal rotation of this last fragment, and then in the formation of a species ready for the product removal, overview | Conticribra weissflogii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | - |
Methanosarcina thermophila | CO2 + H2O | - |
r | |
| H2CO3 | - |
Conticribra weissflogii | CO2 + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carbonic anhydrase | - |
Methanosarcina thermophila |
| carbonic anhydrase | - |
Conticribra weissflogii |
| carbonic anhydrase cambialistic enzyme | - |
Methanosarcina thermophila |
| carbonic anhydrase cambialistic enzyme | - |
Conticribra weissflogii |
| CDCA1 | - |
Methanosarcina thermophila |
| More | the enzyme from Methanosorcina thermophila belongs to the gamma class carbonic anhydrases | Methanosarcina thermophila |
| TWCA1 | - |
Conticribra weissflogii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | carbonic anhydrase represents one of the most ancient proteins | Methanosarcina thermophila |
| evolution | carbonic anhydrase represents one of the most ancient proteins | Conticribra weissflogii |
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