Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.1 extracted from

  • Bertucci, A.; Innocenti, A.; Scozzafava, A.; Tambutte, S.; Zoccola, D.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata (2011), Bioorg. Med. Chem. Lett., 21, 710-714.
    View publication on PubMed
Search for more literature for 4.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl sulfamate
-
 Stylophora pistillata
(6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
 Stylophora pistillata
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
 Stylophora pistillata
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
 Stylophora pistillata
2-aminobenzenesulfonamide
-
 Stylophora pistillata
4,5-dichlorobenzene-1,3-disulfonamide
-
 Stylophora pistillata
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
 Stylophora pistillata
4-(2-aminoethyl)benzenesulfonamide
-
 Stylophora pistillata
4-(aminomethyl)benzenesulfonamide
-
 Stylophora pistillata
4-(ethylamino)-6-(3-methoxypropyl)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
 Stylophora pistillata
4-amino-3,5-dibromobenzenesulfonamide
-
 Stylophora pistillata
4-amino-3,5-diiodobenzenesulfonamide
-
 Stylophora pistillata
4-amino-3-chlorobenzenesulfonamide
-
 Stylophora pistillata
4-amino-3-fluorobenzenesulfonamide
-
 Stylophora pistillata
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
 Stylophora pistillata
4-amino-6-chlorobenzene-1,3-disulfonamide
-
 Stylophora pistillata
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
 Stylophora pistillata
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
 Stylophora pistillata
4-Aminobenzenesulfonamide
-
 Stylophora pistillata
4-hydrazinylbenzenesulfonamide
-
 Stylophora pistillata
4-methylbenzenesulfonamide
-
 Stylophora pistillata
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
 Stylophora pistillata
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
 Stylophora pistillata
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
 Stylophora pistillata
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
 Stylophora pistillata
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
 Stylophora pistillata
acetazolamide
-
 Stylophora pistillata
Br-
-
 Stylophora pistillata
celecoxib
-
 Stylophora pistillata
Cl-
-
 Stylophora pistillata
CN-
-
 Stylophora pistillata
CNO-
-
 Stylophora pistillata
CO32-
-
 Stylophora pistillata
dichlorophenamide
-
 Stylophora pistillata
F-
-
 Stylophora pistillata
H2NSO2NH2
-
 Stylophora pistillata
H2NSO3H
-
 Stylophora pistillata
HCO3-
-
 Stylophora pistillata
HS-
-
 Stylophora pistillata
HSO3-
-
 Stylophora pistillata
I-
-
 Stylophora pistillata
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
 Stylophora pistillata
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
 Stylophora pistillata
N3-
-
 Stylophora pistillata
NO2-
-
 Stylophora pistillata
NO3-
-
 Stylophora pistillata
Ph-AsO3H2
-
 Stylophora pistillata
phenyl-boronic acid
-
 Stylophora pistillata
phenylarsonic acid
-
 Stylophora pistillata
phenylboronic acid
-
 Stylophora pistillata
SCN-
-
 Stylophora pistillata
SO42-
-
 Stylophora pistillata
sulfamic acid
-
 Stylophora pistillata
sulfamide
-
 Stylophora pistillata
valdecoxib
-
 Stylophora pistillata

Localization

Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Stylophora pistillata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
H2CO3 Stylophora pistillata
-
 CO2 + H2O
-
 r

Organism

Organism UniProt Comment Textmining
Stylophora pistillata
-
 isozymes STPCA and STPCA-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
H2CO3
-
 Stylophora pistillata CO2 + H2O
-
 r

Synonyms

Synonyms Comment Organism
carbonic anhydrase
-
 Stylophora pistillata
STPCA
-
 Stylophora pistillata
STPCA-2
-
 Stylophora pistillata

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000016
-
 acetazolamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000074
-
 acetazolamide isozyme STPCA-2, pH 7.5, 20°C Stylophora pistillata
0.000294
-
 4-hydrazinylbenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.0003
-
 4-Aminobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000333
-
 5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000357
-
 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000361
-
 5-amino-1,3,4-thiadiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000481
-
 4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000493
-
 4-amino-3-fluorobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000508
-
 4-(aminomethyl)benzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000516
-
 4-methylbenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.00054
-
 4-amino-3,5-dibromobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000551
-
 4-amino-3-chlorobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000577
-
 4-(2-aminoethyl)benzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000607
-
 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000642
-
 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.00065
-
 4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000661
-
 5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000675
-
 2-aminobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000695
-
 4-amino-3,5-diiodobenzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000701
-
 6-hydroxy-1,3-benzothiazole-2-sulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.00084
-
 4-amino-6-chlorobenzene-1,3-disulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000868
-
 4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.000902
-
 4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide isozyme STPCA, pH 7.5, 20°C Stylophora pistillata
0.0057
-
 H2NSO2NH2 isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.0081
-
 phenyl-boronic acid isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.0085
-
 H2NSO3H isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.0672
-
 Ph-AsO3H2 isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.24
-
 CO32- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.33
-
 SO42- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.43
-
 HSO3- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.51
-
 SCN- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.53
-
 Cl- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.69
-
 CNO- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.86
-
 CN- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.92
-
 F- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.96
-
 Br- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
0.99
-
 NO3- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
3.15
-
 NO2- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
3.94
-
 HS- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
4.68
-
 N3- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
7.81
-
 HCO3- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata
33
-
 I- isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication Stylophora pistillata