Literature summary for 4.2.1.1 extracted from

Carta, F.; Pothen, B.; Maresca, A.; Tiwari, M.; Singh, V.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes (2009), Chem. Biol. Drug Des., 74, 196-202.

Inhibitors

Inhibitors	Comment	Organism
4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide	-	Homo sapiens
4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	-	Homo sapiens
4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide	-	Homo sapiens
4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide	-	Homo sapiens
4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	-	Homo sapiens
4-bromobenzenesulfonamide	-	Homo sapiens
4-chlorobenzenesulfonamide	-	Homo sapiens
4-hydroxybenzenesulfonamide	-	Homo sapiens
4-iodobenzenesulfonamide	-	Homo sapiens
acetazolamide	-	Homo sapiens
dichlorophenamide	-	Homo sapiens
methazolamide	-	Homo sapiens
sulfanilamide	-	Homo sapiens
zonisamide	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	isozyme CA II	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Homo sapiens	H2CO3	-	r

Synonyms

Synonyms	Comment	Organism
CA II	isozyme	Homo sapiens
CA VII	isozyme	Homo sapiens
carbonic anhydrase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.0000021	-	methazolamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.0000025	-	acetazolamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000012	-	acetazolamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000014	-	methazolamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.0000175	-	4-chlorobenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.0000265	-	dichlorophenamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.00003	-	4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000035	-	zonisamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000038	-	dichlorophenamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000046	-	4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000053	-	4-chlorobenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000068	-	4-bromobenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.00007	-	4-iodobenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000081	-	4-iodobenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000081	-	4-bromobenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000088	-	4-hydroxybenzenesulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000089	-	4-hydroxybenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000117	-	zonisamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000277	-	4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000312	-	4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000638	-	4-(4'-dimethylaminophenyl)diazenylbenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000665	-	4-(4'-hydroxyphenyl)diazenylbenzenesulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.000706	-	4-(4'-hydroxyphenyl)diazenylbenzene-N-methylsulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000752	-	4-(4'-hydroxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens
0.000863	-	4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	isozyme CA II, at 25°C, pH 7.4	Homo sapiens
0.0042	-	4-(4'-methoxyphenyl)diazenylbenzene-N,N-dimethylsulfonamide	isozyme CA VII, at 25°C, pH 7.4	Homo sapiens