Literature summary for 4.2.1.1 extracted from

Hilvo, M.; Salzano, A.M.; Innocenti, A.; Kulomaa, M.S.; Scozzafava, A.; Scaloni, A.; Parkkila, S.; Supuran, C.T.
Cloning, expression, post-Translational modifications and inhibition Studies on the latest mammalian carbonic anhydrase isoform, CA XV (2009), J. Med. Chem., 52, 646-654.

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in a baculovirus-Sf9 insect cell expression system	Mus musculus

Inhibitors

Inhibitors	Comment	Organism
2-aminobenzenesulfonamide	-	Mus musculus
2-hydrazinobenzenesulfonamide	-	Mus musculus
4-(2-aminoethyl)benzenesulfonamide	-	Mus musculus
4-(2-hydroxyethyl)benzenesulfonamide	-	Mus musculus
4-(aminomethyl)benzenesulfonamide	-	Mus musculus
4-(hydroxymethyl)benzenesulfonamide	-	Mus musculus
4-amino-3-bromobenzenesulfonamide	-	Mus musculus
4-amino-3-chlorobenzenesulfonamide	-	Mus musculus
4-amino-3-fluorobenzenesulfonamide	-	Mus musculus
4-amino-3-iodobenzenesulfonamide	-	Mus musculus
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide	-	Mus musculus
4-amino-6-chlorobenzene-1,3-disulfonamide	-	Mus musculus
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	-	Mus musculus
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide	-	Mus musculus
4-Aminobenzenesulfonamide	-	Mus musculus
4-hydrazinobenzenesulfonamide	-	Mus musculus
4-methylbenzenesulfonamide	-	Mus musculus
4-sulfamoylbenzoic acid	-	Mus musculus
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide	-	Mus musculus
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide	-	Mus musculus
5-amino-1,3,4-thiadiazole-2-sulfonamide	-	Mus musculus
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide	-	Mus musculus
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide	-	Mus musculus
6-hydroxy-1,3-benzothiazole-2-sulfonamide	-	Mus musculus
acetazolamide	-	Mus musculus
benzolamide	-	Mus musculus
brinzolamide	best isozyme CA XV inhibitor	Mus musculus
celecoxib	best isozyme CA XV inhibitor	Mus musculus
dichlorophenamide	-	Mus musculus
dorzolamide	best isozyme CA XV inhibitor	Mus musculus
ethoxzolamide	best isozyme CA XV inhibitor	Mus musculus
indisulam	-	Mus musculus
methazolamide	best isozyme CA XV inhibitor	Mus musculus
sulpiride	-	Mus musculus
sulthiame	best isozyme CA XV inhibitor	Mus musculus
topiramate	-	Mus musculus
valdecoxib	-	Mus musculus
zonisamide	-	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
14.2	-	CO2	at 20°C and pH 7.5	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Mus musculus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99N23	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CO2 + H2O	-	Mus musculus	H2CO3	-	r

Synonyms

Synonyms	Comment	Organism
Ca XV	-	Mus musculus
carbonic anhydrase XV	-	Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
470000	-	CO2	at 20°C and pH 7.5	Mus musculus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000045	-	celecoxib	at 20°C and pH 7.5	Mus musculus
0.000048	-	5-amino-1,3,4-thiadiazole-2-sulfonamide	at 20°C and pH 7.5	Mus musculus
0.000048	-	5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide	at 20°C and pH 7.5	Mus musculus
0.000049	-	5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide	at 20°C and pH 7.5	Mus musculus
0.000049	-	4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000058	-	ethoxzolamide	at 20°C and pH 7.5	Mus musculus
0.00006	-	5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide	at 20°C and pH 7.5	Mus musculus
0.000061	-	dorzolamide	at 20°C and pH 7.5	Mus musculus
0.000061	-	brinzolamide	at 20°C and pH 7.5	Mus musculus
0.000062	-	4-amino-3-chlorobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000063	-	4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000064	-	6-hydroxy-1,3-benzothiazole-2-sulfonamide	at 20°C and pH 7.5	Mus musculus
0.000065	-	methazolamide	at 20°C and pH 7.5	Mus musculus
0.000065	-	sulthiame	at 20°C and pH 7.5	Mus musculus
0.000066	-	valdecoxib	at 20°C and pH 7.5	Mus musculus
0.000067	-	4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00007	-	benzolamide	at 20°C and pH 7.5	Mus musculus
0.000072	-	acetazolamide	at 20°C and pH 7.5	Mus musculus
0.000072	-	indisulam	at 20°C and pH 7.5	Mus musculus
0.000072	-	4-amino-3-iodobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000073	-	sulpiride	at 20°C and pH 7.5	Mus musculus
0.000078	-	topiramate	at 20°C and pH 7.5	Mus musculus
0.000079	-	4-amino-3-fluorobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000083	-	4-amino-3-bromobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000095	-	dichlorophenamide	at 20°C and pH 7.5	Mus musculus
0.000634	-	zonisamide	at 20°C and pH 7.5	Mus musculus
0.000757	-	4-amino-6-chlorobenzene-1,3-disulfonamide	at 20°C and pH 7.5	Mus musculus
0.000783	-	4-(2-aminoethyl)benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.000926	-	4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide	at 20°C and pH 7.5	Mus musculus
0.00097	-	4-(aminomethyl)benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00456	-	4-(hydroxymethyl)benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00465	-	4-sulfamoylbenzoic acid	at 20°C and pH 7.5	Mus musculus
0.00466	-	4-(2-hydroxyethyl)benzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.006895	-	2-hydrazinobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00799	-	4-methylbenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.008805	-	2-aminobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00954	-	4-hydrazinobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus
0.00961	-	4-Aminobenzenesulfonamide	at 20°C and pH 7.5	Mus musculus